What happens to the concentration of cyclins during the cell cycle?

During the cell cycle, the concentration of cyclins fluctuates significantly as they are crucial regulatory proteins that control the progression of cells through various phases of the cycle. Cyclins are synthesized and degraded in a precise manner in response to the cell's needs.

They begin to accumulate during specific phases, such as G1 and S phases, which are essential for advancing the cell into the next stages like the G2 phase and mitosis. This buildup is followed by a degradation phase, particularly during the metaphase to anaphase transition, where cyclins are marked for destruction to ensure that the cell cycle progresses correctly and does not revert to earlier stages prematurely.

This variation in cyclin levels is essential for the proper regulation of the cell cycle, ensuring that each part of cell division is executed at the right time, which is indicative of the dynamic and carefully tuned nature of cyclins' roles within cellular processes.