What genetic configuration is associated with Klinefelter's syndrome?

Klinefelter's syndrome is actually characterized by the presence of two X chromosomes along with one Y chromosome, making the genetic configuration XXY. This results in a total of three sex chromosomes. Individuals with Klinefelter's syndrome are typically male and can exhibit various physical and developmental traits associated with the condition, such as taller stature, reduced testosterone levels, and potential fertility issues.

The other configurations provided in the choices do not align with the typical genetic makeup for Klinefelter's syndrome. For instance, having only one X chromosome and one Y chromosome would describe a typical male karyotype, while two Y chromosomes and one X or multiple Y chromosomes with one X are configurations not associated with any known genetic conditions in humans, particularly not Klinefelter's syndrome. Thus, the accuracy of the genetic description in this question is crucial for understanding the syndrome's implications.